{\LARGE{Acknowledgment}}

First of all, I want to thank Dr. Bunyarit Uyanonvara to give an opportunity to receive the scholarship from NSTDA-SIIT. Thank for his supportive, guidance and remind me what I should do in each semester and also thank you form gave me the opportunity to choose the research topic I love. His kindness and gentlely has nowhere to be seen along my entire study life. Thank for the advices and comments for every tasks i did in my research from staff at Biostatistics and Informatics Lab, BIOTEC ;P'Chumpol, P'Anunchai, Dr.Ekachai, P'Tle, P'wow, P'Claudia, P'Korn, P'Jing.  They're both very close seniors and friends that i can ????? every time my work failed. 
	I am deeply indebted to my supervisor Prof. Dr. S. Huschek from the Technical University Berlin-Charlottenburg whose help, stimulating suggestions and encouragement helped me in all the time of research for and writing of this thesis.
	Thank for Dr. Sissades Tongsima for both research co-advisor and committee. His protectiveness and kindness encourage me to continue my work no matter how big problems encoutered.
Thank for Assoc. Prof. Sanislave Makanove and Dr. Cholwich to give the professional comments during each presentation to improve my research work and presentation skills. 
	I have furthermore to thank Chief of Student Affairs Division, Ms. Waraporn Thongthua and other staffs who help me manage the registration and financial processes. I am bound to the Honourable Minister Richard Kapelwa Kabajani and to Dr   Peindgondjabi Titus Shipoh, Permanent Secretary in the Ministry of Works, Transport and Communication for their stimulating support. 
	For my former colleagues from Information Technology Program, I want to thank them for all their help, support, interest and valuable hints. Especially I am obliged to P'Kae, P'Cat, P'Ying, Kook, Nut, John and Nong for all his assistance and information in studying course. Thank you P'Kae to for managing the colleagues presentation time in every single semester. 
	Besides, a lot of thanks to my family. They're never doubt when i said I'm going to study. Thanks for every worm feeling when I came home. Nothing I could do without you all.
	Last, I want to thank you for National Center of National Science and Technology Development Agency (NSTDA) and Sirindhorn International Institute of Technology, Thammasat University to give and opportunity to study this valuable research.
